Oh yes! The Heirloom or pure Indica and Sativa plants ? Shut up and TAKE my money!
I think I can sort of pop in here and "swing both ways"....
Mainly because on one hand, I've never gotten to smoke a pure Indica yet, or a pure Sativa for that matter (I mean flowering times, not effects so we're clear on my definition of those words....)
Most of my all time favorites were essentially bred by using landraces; The Cheese line is Skunk #1, which, is some Sativa plants with.... Afghani I think ?
The Chemdog line..... Not even gonna try to guess but given how long it's been around I am going to guess at Landraces bred back and forth.
the Blue Cheese you probably already knew I was going to mention? Well, Skunk#1 X Blueberry, and Blueberry as far as I know is landraces too. Ad Mazar-I-Sharif and you have Skywalker which I also love.
On the other side of that spectrum is GMO that I also really like. Girl Scout Cookies (I'm NOT saying GSC that's dumb, fuck those kids and their cookies leave names alone!.... LOL) is the only cookies strain I've ever actually liked. And liked is an understatement but I haven't smoked it in like 8+ years because I never saw it again, but cross that with Chemdog and you have GMO, which is so interesting given how Girl Scout Cookies tasted LOL! Like how interesting is THAT??? You take something that tastes like a sweet sugar cookie, and you cross it with Chemdog and now it's Onions and Garlic haha! Fuck I love smelling these things.
I was talking to a bud tender at a dispensary one day and he said something that has stuck with me while we were bullshitting; I said that when it came to weed I'm willing to spend money on I follow my nose, and 2 genetic lines (Chem, Cheese) and he said that he felt like maybe the strains that smell the best to us do so because our bodies know which ones we need, so we have a predisposition for certain strains that end up giving us the most benefits. I don't know for sure but that made a lot of sense to me; I mean I come on here sounding perverted as fuck some days like "Oh bro let me smell your nuggets PLEASE!"..... Hahaha.
All my favorites I care the MOST about never had a lab to breed them, and then the Computer Nerd inside me sees "the toys" you can use in a lab to expand what you're looking for and actually finding it, and I can appreciate that too.... I would like a job doing this one day, and if I get laughed out of the interview room because I don't have experience in breeding I can always backdoor their servers and force them to make 300 Cheese crosses for me right?
LOL.