you got me thinking, kinda on a unrelated note...
if
THC (SUPPOSEDLY) slows secretion of TSH from the pituitary gland mostly by regulation of TRH being release in the hypothalamus,
and TSH as we know for sure is associated with an increased risk of lipid and carbohydrate metabolism disorders
and that:
There was one abstract that reported that plasma concentrations of the luteinizing hormone (LH), testosterone, and cortisol were significantly higher in boys using cannabis (n=217), but plasma growth hormone (GH) concentrations were lower during puberty in the cannabis group
Then can I assume that is why most who i've known to use cannabis quite heavily, not necessarily smoking it, always look younger than they really are, and seemingly able to eat everything they want and not be as affected by weight gain? but in reverse for those who are struggling to gain weight, slow the metabolism down to a
normal regulated level, where they have the reverse problem of too high of a metabolism. + gained appetite.
So it keeps us younger, happier, and regulates lipid/metabolism disorders. pretty sweet deal for endomorphs and ectomorphs

and i guess the meso's out there just turn into arnold schwarzenagers like back when he smoked weed, drank beer and ate fried chicken at the beach gym with franko columbu
you got my brain churning, cause i can relate to you in some ways with the alcohol and weed but for me its nicotine. and other thoughts i've had. and i just know when covid cold turkeyed me from alcohol, weed, nicotine, and practically water which was torture to take down...well when i came back to the ganja finally after only craving a very specific high i had in the 2000's, sour diesel, its all i kept thinging about to keep my mind off things...anyways i got a good 40+ day tolerance break, didn't add back in the alcohol or the nicotine, got floored was loving it. till one stressful day i cracked on the nic, and that was when i learned to not combine the two as it confuses my body about cravings and also the effects of cannabis singularly. i don't mix em now sheerly so i can enjoy cannabis effects fully, and make sure i limit my use of concentrates/rosin, havent had a dab in years, but i was using my hot nail on bubble hash for a few days recently and it definitely impacted how I experience normal flower, and quickly got a tollerance to the nail..but its normalized now.
Running diverse seedpools that aren't completely homogenous helps with my tollerance the most. Unless i'm after a very specific terp profile or plant, i like sifting through things that have 3+ phenotypes, cycle through those and keep my tollerance down from the varying enteurage effects. but typically i'm just popping 6+ different strains to be sure. but i'll cater to the effects i want so i'm at least in the ball park, fewer coucher lockers than the cerebral dragon up the spine types typically for me.